Anti-Remodeling and Anti-Fibrotic Effects of the Neuregulin-1b Glial Growth Factor 2 in a Large Animal Model of Heart Failure
نویسندگان
چکیده
Cristi L. Galindo, PhD;* Ehab Kasasbeh, MD;* Abigail Murphy, BA; Sergey Ryzhov, MD, PhD; Sean Lenihan; Farhaan A. Ahmad, MD; Philip Williams, PhD; Amy Nunnally, BS; Jamie Adcock, BS; Yanna Song, PhD; Frank E. Harrell, PhD; Truc-Linh Tran, BS; Tom J. Parry, PhD; Jen Iaci, MS; Anindita Ganguly, PhD; Igor Feoktistov, MD, PhD; Matthew K. Stephenson, PhD; Anthony O. Caggiano, MD, PhD; Douglas B. Sawyer, MD, PhD; John H. Cleator, MD, PhD
منابع مشابه
Anti‐Remodeling and Anti‐Fibrotic Effects of the Neuregulin‐1β Glial Growth Factor 2 in a Large Animal Model of Heart Failure
BACKGROUND Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large animal model of cardiac injury has not been examined. We therefore sought to e...
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